26/01/2008 – San Luis – Mirador de Potreros (provisional) (132 km)
| Rank | Nat | Coureur | Team | Tijd |
| 1 | VEN | Carlos José Ochoa | SDA | 3:50:25 |
| 2 | SPA | Benat Intxausti Elorriaga | SDV | +0:06 |
| 3 | COL | Jose Rodolfo Serpa Perez | SDA | +0:06 |
| 4 | LUX | Frank Schleck | CSC | +0:17 |
| 5 | VEN | Jackson Jesus Rodriguez Ortiz | SDA | +0:23 |
| 6 | ARG | Luciano Montivero | - | +0:23 |
| 7 | ARG | Sergio Godoy | - | +0:23 |
| 8 | ARG | Jorge Giacinti | - | +0:23 |
| 9 | ARG | Gerardo Luis Fernandez | - | +0:23 |
| 10 | ARG | Guillermo Gaston Aguero | - | +0:27 |
